Skip to main content

Hyaluronic Acid: Comparing Effects Based on Molecular Size

 

Table of Contents


1. Introduction to Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring substance in the skin that helps to keep it hydrated and plump. The effectiveness of HA can vary depending on its molecular weight, which is measured in Daltons (Da). Different molecular weights offer unique benefits to the skin.



2. Low Molecular Weight Hyaluronic Acid

Low molecular weight HA (LMW-HA), typically ranging from 5 to 200 kDa, has the ability to penetrate deeper into the skin's layers. This allows it to provide hydration from within, which can lead to several benefits:

  • Deep Hydration: Penetrates the dermis layer to hydrate deeply. (Stanford Chemicals)
  • Reduced Signs of Aging: Can help minimize the appearance of fine lines and wrinkles. (Amala Beauty)
  • Enhanced Skin Barrier: Provides deep hydration, strengthening the skin's barrier function.
  • Anti-inflammatory Benefits: May help reduce redness, irritation, and inflammation. 
  • Stimulates Collagen and Elastin: Can promote the production of these essential proteins for skin elasticity. 


3. Medium Molecular Weight Hyaluronic Acid

Medium molecular weight HA (MMW-HA), ranging from 200 to 1,800 kDa, penetrates the surface layers of the skin and rapidly improves epidermal hydration. It helps to maintain improved skin hydration throughout the day. (Filorga, Stanford Chemicals)



4. High Molecular Weight Hyaluronic Acid

High molecular weight HA (HMW-HA), typically ≥ 1,800 kDa, primarily works on the skin's surface. Its larger molecular structure allows it to form a moisture-retentive film, providing:

  • Superior Surface Hydration: Creates a film that locks in moisture. (Hyaluronic Acid Supplier)
  • Long-Lasting Hydration: The moisture-retentive film provides sustained hydration. 
  • Protective Barrier: The film also helps to protect the skin from environmental stressors. 
  • Anti-inflammatory Effects: May exhibit anti-inflammatory properties on the skin's surface. (Ultrasound Guided Injections)


5. Comparison Table

Here's a table summarizing the key differences based on molecular weight:

Molecular Weight Size (kDa) Penetration Key Benefits
Low 5 - 200 Deep Deep hydration, reduces wrinkles, strengthens barrier, anti-inflammatory, stimulates collagen/elastin
Medium 200 - 1,800 Surface layers Rapid epidermal hydration, maintains hydration
High ≥ 1,800 Surface Superior surface hydration, long-lasting moisture, protective barrier, anti-inflammatory


6. Conclusion

The molecular weight of hyaluronic acid significantly impacts its effects on the skin. Low molecular weight HA offers deep hydration and anti-aging benefits, while high molecular weight HA provides excellent surface hydration and barrier protection. Often, skincare formulations combine different molecular weights of HA to deliver comprehensive hydration and address various skin concerns.



Labels:

Popular posts from this blog

Panthenol: Strengthening the Skin Barrier and Moisturizing Simultaneously!

  Table of Contents 1. Introduction to Panthenol 2. Strengthening the Skin Barrier 3. Powerful Moisturizing Properties 4. Other Benefits of Panthenol for Skin 5. Conclusion 6. Related Posts 1. Introduction to Panthenol Panthenol, also known as pro-vitamin B5 , is a popular ingredient in skincare products due to its versatile benefits. It's well-regarded for its ability to both strengthen the skin's natural barrier and provide deep hydration , making it a go-to ingredient for maintaining healthy and resilient skin. 2. Strengthening the Skin Barrier A healthy skin barrier is essential for protecting the skin from external aggressors and preventing moisture loss . Panthenol plays a vital role in fortifying this barrier: Enhances Lipid Synthesis : Panthenol can promote the repair of the skin barrier by enhancing the synthesis of lip...
Read more

Olive Young vs Chicor vs LOHB's: Where to Shop for K-Beauty?

Table of Contents Why is K-Beauty Shopping So Confusing? Olive Young: The Heart of Popular K-Beauty Chicor: Experiencing Department Store Beauty Freely LOHB's: The Joy of Finding Hidden Gems Which K-Beauty Store is Right for You? Smart Shopping Tips for K-Beauty Related Posts 1. Why is K-Beauty Shopping So Confusing? Korean beauty products, or K-Beauty, are incredibly popular worldwide. But when you're ready to shop, it can be tricky to know where to go. There are many well-known H&B (Health & Beauty) stores like Olive Young, Chicor, and LOHB's. Each store has a different selection of brands, atmosphere, and sales events, making it confusing to figure out which one is best for finding exactly what you need. This article will compare each store's unique features to help you navigate your K-Beauty shopping journey. 2. Olive Young: The Heart of Popul...
Read more

세라마이드: 피부 장벽 강화의 필수 성분

    목차 피부 장벽의 핵심 구성 요소, 세라마이드란? 세라마이드가 피부 장벽을 강화하는 과학적 원리 세라마이드 부족 시 나타나는 피부 문제 세라마이드의 다양한 피부 효능 세라마이드 제품, 현명하게 선택하고 사용하기 세라마이드와 함께 사용하면 좋은 시너지 성분 세라마이드, 건강한 피부를 위한 필수 투자 건조하고 민감하며 쉽게 트러블이 올라오는 피부 때문에 고민이신가요? 아무리 좋은 제품을 발라도 속당김이 해소되지 않고, 외부 자극에 쉽게 붉어지는 피부라면 '피부 장벽'에 문제가 있을 가능성이 큽니다. 우리 피부의 가장 바깥층에 있는 이 장벽은 외부 유해 물질로부터 피부를 보호하고 내부의 수분 증발을 막아주는 핵심 방어선입니다. 그리고 이 중요한 피부 장벽을 튼튼하게 유지하는 데 없어서는 안 될 필수적인 성분이 바로 '세라마이드(Ceramide)'입니다. 지금부터 당신의 피부를 튼튼하게 지켜줄 세라마이드의 비밀을 파헤쳐 봅시다! 1. 피부 장벽의 핵심 구성 요소, 세라마이드란? 세라마이드는 피부 표피층(특히 각질층)에 존재하는 지질(脂質, Fat)의 일종으로, 콜레스테롤, 지방산과 함께 피부 장벽을 구성하는 핵심 성분입니다. 우리 피부의 각질 세포는  벽돌처럼 쌓여 있고, 그 사이를 메워주는 시멘트 같은 역할을 하는 것이 바로 이 세라마이드를 포함한 지질 성분들입니다. 세라마이드는 각질층 지질의 약 50%를 차지하며, 이는 피부 장벽의 견고함에 결정적인 영향을 미칩니다. 우리 몸에는 다양한 종류의 세라마이드(예: 세라마이드 NP, AP, EOP 등)가 존재하며, 이들이 복합적으로 작용하여 피부 장벽 기능을 수행합니다. 2. 세라마이드가 피부 장벽을 강화하는 과학적 원리 세라마이드는 피부 장벽을 튼튼하게 하는 데 핵심적인 역할을 하는 ...
Read more